7qqd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Nuclear factor one X - NFIX in P21== |
| - | + | <StructureSection load='7qqd' size='340' side='right'caption='[[7qqd]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7qqd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QQD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qqd OCA], [https://pdbe.org/7qqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qqd RCSB], [https://www.ebi.ac.uk/pdbsum/7qqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qqd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NFIX_HUMAN NFIX_HUMAN] Marshall-Smith syndrome;Malan overgrowth syndrome;19p13.3 microduplication syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NFIX_HUMAN NFIX_HUMAN] Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Bais G]] | ||
| + | [[Category: Chaves-Sanjuan A]] | ||
| + | [[Category: Demitri N]] | ||
| + | [[Category: Gourlay LJ]] | ||
| + | [[Category: Lapi M]] | ||
| + | [[Category: Nardini M]] | ||
| + | [[Category: Polentarutti M]] | ||
| + | [[Category: Tiberi M]] | ||
Current revision
Nuclear factor one X - NFIX in P21
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