7q6w
From Proteopedia
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==Crystal structure of the bromodomain of ATAD2 with triazolopyridazine (cpd 22)== | ==Crystal structure of the bromodomain of ATAD2 with triazolopyridazine (cpd 22)== | ||
| - | <StructureSection load='7q6w' size='340' side='right'caption='[[7q6w]]' scene=''> | + | <StructureSection load='7q6w' size='340' side='right'caption='[[7q6w]], [[Resolution|resolution]] 1.96Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q6W FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7q6w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q6W FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q6w OCA], [https://pdbe.org/7q6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q6w RCSB], [https://www.ebi.ac.uk/pdbsum/7q6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q6w ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=93L:(1R,9S)-13-[[3-methyl-8-[(1-methylpiperidin-4-yl)amino]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]carbonyl]-11,13-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4,6-trien-10-one'>93L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q6w OCA], [https://pdbe.org/7q6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q6w RCSB], [https://www.ebi.ac.uk/pdbsum/7q6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q6w ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | ||
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| + | ==See Also== | ||
| + | *[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Patel SJ]] | [[Category: Patel SJ]] | ||
[[Category: Winter-Holt JJ]] | [[Category: Winter-Holt JJ]] | ||
Current revision
Crystal structure of the bromodomain of ATAD2 with triazolopyridazine (cpd 22)
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