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6x7i
From Proteopedia
(Difference between revisions)
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<StructureSection load='6x7i' size='340' side='right'caption='[[6x7i]]' scene=''> | <StructureSection load='6x7i' size='340' side='right'caption='[[6x7i]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[6x7i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X7I FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x7i OCA], [https://pdbe.org/6x7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x7i RCSB], [https://www.ebi.ac.uk/pdbsum/6x7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x7i ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x7i OCA], [https://pdbe.org/6x7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x7i RCSB], [https://www.ebi.ac.uk/pdbsum/6x7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x7i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bcl-xL is a major inhibitor of apoptosis, a fundamental homeostatic process of programmed cell death that is highly conserved across evolution. Because it plays prominent roles in cancer, Bcl-xL is a major target for anticancer therapy and for studies aimed at understanding its structure and activity. Although Bcl-xL is active primarily at intracellular membranes, most studies have focused on soluble forms of the protein lacking both the membrane-anchoring C-terminal tail and the intrinsically disordered loop, and this has resulted in a fragmented view of the protein's biological activity. Here, we describe the conformation of full-length Bcl-xL. Using NMR spectroscopy, molecular dynamics simulations, and isothermal titration calorimetry, we show how the three structural elements affect the protein's structure, dynamics, and ligand-binding activity in both its soluble and membrane-anchored states. The combined data provide information about the molecular basis for the protein's functionality and a view of its complex molecular mechanisms. | ||
| + | |||
| + | Conformational States of the Cytoprotective Protein Bcl-xL.,Ryzhov P, Tian Y, Yao Y, Bobkov AA, Im W, Marassi FM Biophys J. 2020 Oct 6;119(7):1324-1334. doi: 10.1016/j.bpj.2020.08.014. Epub 2020, Aug 20. PMID:32888404<ref>PMID:32888404</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6x7i" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Marassi FM]] | [[Category: Marassi FM]] | ||
[[Category: Tian Y]] | [[Category: Tian Y]] | ||
[[Category: Yao Y]] | [[Category: Yao Y]] | ||
Current revision
Structure of the C-terminal domain of BCL-XL in membrane
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