Sandbox E20
From Proteopedia
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==Results== | ==Results== | ||
| - | The X-ray structure of the E2020-''Tc''AChE complex shows that E2020 has a <scene name=' | + | The X-ray structure of the E2020-''Tc''AChE complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/13'>unique orientation</scene> along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/7'>W84</scene>) of the active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/5'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <scene name='1eve/E20_interactionshown/8'>indirectly via solvent molecules</scene>. |
==Conclusions== | ==Conclusions== | ||
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| - | <scene name='90/902074/ | + | <scene name='90/902074/Cartoon_and_e20/1'>cartoon_and_E2020</scene> |
<jmol> | <jmol> | ||
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</jmolCheckbox> | </jmolCheckbox> | ||
</jmol> | </jmol> | ||
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| + | <scene name='90/902074/T/1'>residues near E2020</scene> | ||
==About this Structure== | ==About this Structure== | ||
Current revision
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Reference
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs., Kryger G, Silman I, Sussman JL, Structure. 1999 Mar 15;7(3):297-307. PMID:10368299
