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1g6q

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[[Image:1g6q.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF YEAST ARGININE METHYLTRANSFERASE, HMT1==
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The line below this paragraph, containing "STRUCTURE_1g6q", creates the "Structure Box" on the page.
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<StructureSection load='1g6q' size='340' side='right'caption='[[1g6q]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1g6q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G6Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g6q OCA], [https://pdbe.org/1g6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g6q RCSB], [https://www.ebi.ac.uk/pdbsum/1g6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g6q ProSAT]</span></td></tr>
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{{STRUCTURE_1g6q| PDB=1g6q | SCENE= }}
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</table>
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== Function ==
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'''CRYSTAL STRUCTURE OF YEAST ARGININE METHYLTRANSFERASE, HMT1'''
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[https://www.uniprot.org/uniprot/HMT1_YEAST HMT1_YEAST] Methylates arginines in a variety of RNA-binding proteins. Methylates NOP3. Can catalyze both the mono- and asymmetric dimethylation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Protein methylation at arginines is ubiquitous in eukaryotes and affects signal transduction, gene expression and protein sorting. Hmt1/Rmt1, the major arginine methyltransferase in yeast, catalyzes methylation of arginine residues in several mRNA-binding proteins and facilitates their export from the nucleus. We now report the crystal structure of Hmt1 at 2.9 A resolution. Hmt1 forms a hexamer with approximate 32 symmetry. The surface of the oligomer is dominated by large acidic cavities at the dimer interfaces. Mutation of dimer contact sites eliminates activity of Hmt1 both in vivo and in vitro. Mutating residues in the acidic cavity significantly reduces binding and methylation of the substrate Npl3.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/1g6q_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1G6Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6Q OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g6q ConSurf].
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The structure and oligomerization of the yeast arginine methyltransferase, Hmt1., Weiss VH, McBride AE, Soriano MA, Filman DJ, Silver PA, Hogle JM, Nat Struct Biol. 2000 Dec;7(12):1165-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11101900 11101900]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Filman DJ]]
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[[Category: Filman, D J.]]
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[[Category: Hogle JM]]
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[[Category: Hogle, J M.]]
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[[Category: McBride AE]]
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[[Category: McBride, A E.]]
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[[Category: Silver PA]]
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[[Category: Silver, P A.]]
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[[Category: Soriano MA]]
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[[Category: Soriano, M A.]]
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[[Category: Weiss VH]]
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[[Category: Weiss, V H.]]
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[[Category: Beta-barrel]]
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[[Category: Dimer]]
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[[Category: Hexamer]]
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[[Category: Mixed alpha-beta]]
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[[Category: Sam-binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:12:30 2008''
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Current revision

CRYSTAL STRUCTURE OF YEAST ARGININE METHYLTRANSFERASE, HMT1

PDB ID 1g6q

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