1g6r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:19, 27 March 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1g6r.gif|left|200px]]
 
-
<!--
+
==A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX==
-
The line below this paragraph, containing "STRUCTURE_1g6r", creates the "Structure Box" on the page.
+
<StructureSection load='1g6r' size='340' side='right'caption='[[1g6r]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1g6r]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G6R FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g6r OCA], [https://pdbe.org/1g6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g6r RCSB], [https://www.ebi.ac.uk/pdbsum/1g6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g6r ProSAT]</span></td></tr>
-
{{STRUCTURE_1g6r| PDB=1g6r | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TVA1_MOUSE TVA1_MOUSE]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/1g6r_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g6r ConSurf].
 +
<div style="clear:both"></div>
-
'''A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX'''
+
==See Also==
-
 
+
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-
 
+
*[[MHC 3D structures|MHC 3D structures]]
-
==Overview==
+
*[[MHC I 3D structures|MHC I 3D structures]]
-
A longstanding question in T cell receptor signaling is how structurally similar ligands, with similar affinities, can have substantially different biological activity. The crystal structure of the 2C TCR complex of H-2Kb with superagonist peptide SIYR at 2.8 A elucidates a structural basis for TCR discrimination of altered peptide ligands. The difference in antigen potency is modulated by two cavities in the TCR combining site, formed mainly by CDRs 3alpha, 3beta, and 1beta, that complement centrally located peptide residues. This "functional hot spot" allows the TCR to finely discriminate amongst energetically similar interactions within different ligands for those in which the peptide appropriately stabilizes the TCR/pMHC complex and provides a new structural perspective for understanding differential signaling resulting from T cell cross-reactivity.
+
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
1G6R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6R OCA].
+
[[Category: Large Structures]]
-
 
+
-
==Reference==
+
-
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex., Degano M, Garcia KC, Apostolopoulos V, Rudolph MG, Teyton L, Wilson IA, Immunity. 2000 Mar;12(3):251-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10755612 10755612]
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Protein complex]]
+
[[Category: Apostolopoulos V]]
-
[[Category: Apostolopoulos, V.]]
+
[[Category: Degano M]]
-
[[Category: Degano, M.]]
+
[[Category: Garcia KC]]
-
[[Category: Garcia, K C.]]
+
[[Category: Rudolph MG]]
-
[[Category: Rudolph, M G.]]
+
[[Category: Teyton L]]
-
[[Category: Teyton, L.]]
+
[[Category: Wilson IA]]
-
[[Category: Wilson, I A.]]
+
-
[[Category: Major histocompatibility complex]]
+
-
[[Category: Superagonist]]
+
-
[[Category: T cell antigen receptor]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:12:33 2008''
+

Current revision

A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX

PDB ID 1g6r

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g6r"
Personal tools