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2k9o
From Proteopedia
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==Solution structure of Vm24 synthetic scorpion toxin== | ==Solution structure of Vm24 synthetic scorpion toxin== | ||
| - | <StructureSection load='2k9o' size='340' side='right'caption='[[2k9o | + | <StructureSection load='2k9o' size='340' side='right'caption='[[2k9o]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2k9o]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9O FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2k9o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaejovis_smithi Vaejovis smithi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9O FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9o OCA], [https://pdbe.org/2k9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9o RCSB], [https://www.ebi.ac.uk/pdbsum/2k9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9o ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9o OCA], [https://pdbe.org/2k9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9o RCSB], [https://www.ebi.ac.uk/pdbsum/2k9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KA231_VAEMS KA231_VAEMS] Voltage-gated potassium channel inhibitor. Selectively and irreversibly binds (K(d)=2.9 pM) and blocks hKv1.3/KCNA3 potassium channels of human T-lymphocytes. Weakly blocks hKCa3.1/KCNN4, mKv1.1/KCNA1, and hKv1.2/KCNA2 channels. In vivo, high doses (200 ug) produce no symptoms of intoxication when injected into mice.<ref>PMID:22540187</ref> <ref>PMID:22622363</ref> <ref>PMID:22540187</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Gurrola | + | [[Category: Vaejovis smithi]] |
| - | [[Category: Hernandez-Lopez | + | [[Category: Gurrola G]] |
| - | [[Category: Possani-Postay | + | [[Category: Hernandez-Lopez R]] |
| - | [[Category: Rio-Portilla | + | [[Category: Possani-Postay L]] |
| - | + | [[Category: Del Rio-Portilla F]] | |
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Current revision
Solution structure of Vm24 synthetic scorpion toxin
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