2kf8

<StructureSection load='2kf8' size='340' side='right'caption='[[2kf8]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[143d|143d]], [[1k8p|1k8p]], [[2gku|2gku]], [[2aqy|2aqy]], [[2jsk|2jsk]], [[2jsl|2jsl]], [[2jsm|2jsm]], [[2jsq|2jsq]], [[2kf7|2kf7]]</div></td></tr>

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== Publication Abstract from PubMed ==

Previously, it has been reported that human telomeric DNA sequences could adopt in different experimental conditions four different intramolecular G-quadruplexes each involving three G-tetrad layers, namely, Na(+) solution antiparallel-stranded basket form, K(+) crystal parallel-stranded propeller form, K(+) solution (3 + 1) Form 1, and K(+) solution (3 + 1) Form 2. Here we present a new intramolecular G-quadruplex adopted by a four-repeat human telomeric sequence in K(+) solution (Form 3). This structure is a basket-type G-quadruplex with only two G-tetrad layers: loops are successively edgewise, diagonal, and edgewise; glycosidic conformations of guanines are syn*syn*anti*anti around each tetrad. Each strand of the core has both a parallel and an antiparallel adjacent strands; there are one narrow, one wide, and two medium grooves. Despite the presence of only two G-tetrads in the core, this structure is more stable than the three-G-tetrad intramolecular G-quadruplexes previously observed for human telomeric sequences in K(+) solution. Detailed structural elucidation of Form 3 revealed extensive base pairing and stacking in the loops capping both ends of the G-tetrad core, which might explain the high stability of the structure. This novel structure highlights the conformational heterogeneity of human telomeric DNA. It establishes a new folding principle for G-quadruplexes and suggests new loop sequences and structures for targeting in human telomeric DNA.

Structure of the Human Telomere in K(+) Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers.,Lim KW, Amrane S, Bouaziz S, Xu W, Mu Y, Patel DJ, Luu KN, Phan AT J Am Chem Soc. 2009 Mar 9. PMID:19271707<ref>PMID:19271707</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2kf8" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Amrane, S]]

[[Category: Bouaziz, S]]

[[Category: Lim, K W]]

[[Category: Luu, K N]]

[[Category: Mu, Y]]

[[Category: Patel, D J]]

[[Category: Phan, A T]]

[[Category: Xu, W]]

[[Category: Intramolecular g-quadruplex]]