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3c72

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Engineered RabGGTase in complex with a peptidomimetic inhibitor

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Retrieved from "http://52.214.119.220/wiki/index.php/3c72"

@@ Line 3: / Line 3: @@
 <StructureSection load='3c72' size='340' side='right'caption='[[3c72]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3c72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C72 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3c72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C72 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CX1:N-[(BENZYLOXY)CARBONYL]-L-HISTIDYL-N-METHYL-L-PHENYLALANYL-L-TYROSINE'>CX1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rabggta, Ggta ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Rabggtb, Ggtb ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CX1:N-[(BENZYLOXY)CARBONYL]-L-HISTIDYL-N-METHYL-L-PHENYLALANYL-L-TYROSINE'>CX1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c72 OCA], [https://pdbe.org/3c72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c72 RCSB], [https://www.ebi.ac.uk/pdbsum/3c72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c72 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [[https://www.uniprot.org/uniprot/PGTB2_RAT PGTB2_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.
+[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 26: / Line 25: @@
 __TOC__
 </StructureSection>
-[[Category: Buffalo rat]]
 [[Category: Large Structures]]
-[[Category: Protein geranylgeranyltransferase type II]]
+[[Category: Rattus norvegicus]]
-[[Category: Alexandrov, K]]
+[[Category: Alexandrov K]]
-[[Category: Arndt, S]]
+[[Category: Arndt S]]
-[[Category: Blankenfeldt, W]]
+[[Category: Blankenfeldt W]]
-[[Category: Bon, R S]]
+[[Category: Bon RS]]
-[[Category: Delon, C]]
+[[Category: Delon C]]
-[[Category: Goody, R S]]
+[[Category: Goody RS]]
-[[Category: Guiu-Rozas, E]]
+[[Category: Guiu-Rozas E]]
-[[Category: Guo, Z]]
+[[Category: Guo Z]]
-[[Category: Nguyen, U T]]
+[[Category: Nguyen UT]]
-[[Category: Tan, K T]]
+[[Category: Tan KT]]
-[[Category: Waldmann, H]]
+[[Category: Waldmann H]]
-[[Category: Wetzel, S]]
+[[Category: Wetzel S]]
-[[Category: Wu, Y W]]
+[[Category: Wu YW]]
-[[Category: Metal-binding]]
-[[Category: Peptide inhibitor]]
-[[Category: Phosphoprotein]]
-[[Category: Prenyltransferase]]
-[[Category: Rab prenylation]]
-[[Category: Transferase]]

3c72

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Current revision

Engineered RabGGTase in complex with a peptidomimetic inhibitor

Structural highlights

Function

Evolutionary Conservation

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