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Sandbox Test M
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==AlphaFold2 Model of Sars-CoV-2 Protein M== | ==AlphaFold2 Model of Sars-CoV-2 Protein M== | ||
| - | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='90/902730/Sars-cov-2_protein_m/ | + | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='90/902730/Sars-cov-2_protein_m/3'> |
| - | {{Theoretical_model}} | + | {{Theoretical_model}} {{Template:ModelConfidence}} |
| - | = | + | To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein (UniProt ID: QHD43419) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 4<ref name="MIT_ColabFold"> MIT ColabFold https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb </ref>. |
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== Function == | == Function == | ||
'''Protein M''' | '''Protein M''' | ||
| - | Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref> | + | Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>] |
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| + | [[Image:SARSCoV2_protein_M_250.gif|250px|left|thumb|'''Morph''' of the top 5 ranked [[AlphaFold]]2 models of '''SARS-CoV-2 Protein M''', ''rainbow'' color coded N-C<ref name="MIT_ColabFold"/>.]] | ||
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== See also == | == See also == | ||
Current revision
AlphaFold2 Model of Sars-CoV-2 Protein M
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References
- ↑ 1.0 1.1 MIT ColabFold https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb
- ↑ Modeling of the SARS-COV-2 Genome
- ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129
