Portal protein
From Proteopedia
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== Function == | == Function == | ||
The '''portal protein''' (PP) is a key component during viral chromosomal packaging. PPs have a central channel through which DNA movements occur. PPs are proposed to be the mechanical device that pumps DNA to the interior of the viral capsid<ref>PMID:15110523</ref>. The DNA translocation motor is composed of PP and of the the viral ATPase that fuels DNA translocation. The PP has an active control over the viral ATPase activity<ref>PMID:16735502</ref>. | The '''portal protein''' (PP) is a key component during viral chromosomal packaging. PPs have a central channel through which DNA movements occur. PPs are proposed to be the mechanical device that pumps DNA to the interior of the viral capsid<ref>PMID:15110523</ref>. The DNA translocation motor is composed of PP and of the the viral ATPase that fuels DNA translocation. The PP has an active control over the viral ATPase activity<ref>PMID:16735502</ref>. | ||
| - | + | == 3D Structures of portal protein == | |
| + | [[Portal protein 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of portal protein == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Portal protein | ||
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| - | **[[2jes]] – Spp1Gp6 – Bacteriophage Spp1 <br /> | ||
| - | **[[3lj5]], [[5jj1]], [[5jj3]] – P22Gp1 – Bacteriophage P22 <br /> | ||
| - | **[[6qx7]], [[6qyj]], [[6qym]] – P29PP – Bacteriophage P29 – Cryo EM <br /> | ||
| - | **[[6qwp]], [[6qx5]], [[6tjp]] – T7PP – Bacteriophage T7 <br /> | ||
| - | **[[6qxm]], [[7bou]], [[7bp0]], [[7ey6]], [[7ey8]] – T7PP – Cryo EM <br /> | ||
| - | **[[6qx7]], [[6qyj]], [[6qym]] – BpPP – Bacteriophage φ29 – Cryo EM<br /> | ||
| - | **[[4zjn]], [[6ibg]] – G20CPP – Bacteriophage G20C <br /> | ||
| - | **[[5ngd]] – G20CPP (mutant)<br /> | ||
| - | **[[3ja7]] – T4Gp20 – Bacteriophage T4 – Cryo EM<br /> | ||
| - | **[[6qjt]] – P23 – Thermus virus – Cryo EM<br /> | ||
| - | **[[3kdr]] – HK97 – ''Corynebacterium diphtheriae'' <br /> | ||
| - | **[[6od7]] – PP – human herpesvirus 1 – Cryo EM <br /> | ||
| - | **[[6rvr]], [[6rvs]], [[7bqt]] – PP – human herpesvirus 4 – Cryo EM <br /> | ||
| - | **[[7et2]], [[7etm]] – PP – human herpesvirus 5 – Cryo EM <br /> | ||
| - | **[[6ppi]] – PP – human herpesvirus 8 – Cryo EM <br /> | ||
| - | **[[6qjt]] – PP – Thermus virus – Cryo EM <br /> | ||
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| - | *Portal protein complexes | ||
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| - | **[[5a21]], [[5a20]] – Spp1Gp6 + Gp15 + Gp16 + Gp17 – Cryo EM<br /> | ||
| - | **[[4v4k]] – P22Gp1 + Gp4 <br /> | ||
| - | **[[5gai]] – P22Gp1 + Gp4 + Gp6 – Cryo EM <br /> | ||
| - | **[[6iac]] – PP + lower collar protein + minor structural protein + inner core protein – Staphylococcus phage P68 – Cryo EM <br /> | ||
| - | **[[6qz9]], [[6qzf]] – BpPP + neck appendage protein + tail tube protein – Cryo EM <br /> | ||
| - | **[[6iac]] – PP + lower collar protein + minor structural protein + inner core protein - Staphylococcus phage P68 – Cryo EM <br /> | ||
| - | **[[6tba]], [[6te8]], [[6te9]], [[6to8]], [[6toa]], [[6tui]] – PP in GTA particle – rhodobacter capsulatus – Cryo EM <br /> | ||
| - | **[[6uzc]] – T4PP + major capsid protein – Cryo EM<br /> | ||
| - | **[[6r21]] – T7PP in tail complex – Cryo EM<br /> | ||
| - | **[[7kln]] – PP + Gp1 – Vibrio phage XM1 - Cryo EM <br /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Isidro A, Henriques AO, Tavares P. The portal protein plays essential roles at different steps of the SPP1 DNA packaging process. Virology. 2004 May 1;322(2):253-63. doi: 10.1016/j.virol.2004.02.012. PMID:15110523 doi:http://dx.doi.org/10.1016/j.virol.2004.02.012
- ↑ Oliveira L, Henriques AO, Tavares P. Modulation of the viral ATPase activity by the portal protein correlates with DNA packaging efficiency. J Biol Chem. 2006 Aug 4;281(31):21914-23. doi: 10.1074/jbc.M603314200. Epub 2006 , May 30. PMID:16735502 doi:http://dx.doi.org/10.1074/jbc.M603314200
