7qs8

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'''Unreleased structure'''
 
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The entry 7qs8 is ON HOLD until Paper Publication
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==Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1==
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<StructureSection load='7qs8' size='340' side='right'caption='[[7qs8]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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Authors: Javorsky, A., Soares da Costa, T.P., Mackie, E.R., Humbert, P.O., Kvansakul, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7qs8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_T-cell_leukemia_virus_type_I Human T-cell leukemia virus type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QS8 FirstGlance]. <br>
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Description: Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qs8 OCA], [https://pdbe.org/7qs8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qs8 RCSB], [https://www.ebi.ac.uk/pdbsum/7qs8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qs8 ProSAT]</span></td></tr>
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[[Category: Kvansakul, M]]
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</table>
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[[Category: Humbert, P.O]]
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== Disease ==
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[[Category: Mackie, E.R]]
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[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Javorsky, A]]
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== Function ==
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[[Category: Soares Da Costa, T.P]]
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[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human T-cell leukemia virus type I]]
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[[Category: Large Structures]]
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[[Category: Humbert PO]]
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[[Category: Javorsky A]]
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[[Category: Kvansakul M]]
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[[Category: Mackie ER]]
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[[Category: Soares da Costa TP]]

Current revision

Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1

PDB ID 7qs8

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