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7qxf
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7qxf is ON HOLD Authors: Dobritzsch, D., Widersten, M., Engel, S. Description: Fructose-6-phosphate aldolase (FSA) mutant R134V, S166G, with covale...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Fructose-6-phosphate aldolase (FSA) mutant R134V, S166G, with covalently bound active site ligand== | |
| - | + | <StructureSection load='7qxf' size='340' side='right'caption='[[7qxf]], [[Resolution|resolution]] 2.62Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7qxf]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QXF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I2F:(2~{S},4~{R},5~{E})-5-[(5~{S})-5-azanyl-6-oxidanyl-hexyl]iminohexane-1,2,4-triol'>I2F</scene></td></tr> |
| - | [[Category: Dobritzsch | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qxf OCA], [https://pdbe.org/7qxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qxf RCSB], [https://www.ebi.ac.uk/pdbsum/7qxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qxf ProSAT]</span></td></tr> |
| - | [[Category: Engel | + | </table> |
| - | [[Category: Widersten | + | == Function == |
| + | [https://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dobritzsch D]] | ||
| + | [[Category: Engel S]] | ||
| + | [[Category: Widersten M]] | ||
Current revision
Fructose-6-phosphate aldolase (FSA) mutant R134V, S166G, with covalently bound active site ligand
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