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7lvg
From Proteopedia
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<StructureSection load='7lvg' size='340' side='right'caption='[[7lvg]]' scene=''> | <StructureSection load='7lvg' size='340' side='right'caption='[[7lvg]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7lvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Juglans_regia Juglans regia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LVG FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lvg OCA], [https://pdbe.org/7lvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lvg RCSB], [https://www.ebi.ac.uk/pdbsum/7lvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lvg ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lvg OCA], [https://pdbe.org/7lvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lvg RCSB], [https://www.ebi.ac.uk/pdbsum/7lvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lvg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VCL2_JUGRE VCL2_JUGRE] Seed storage protein.<ref>PMID:10589017</ref> <ref>PMID:21883278</ref> <ref>PMID:25388987</ref> <ref>PMID:30054513</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Vicilin-buried peptides (VBPs) from edible plants are derived from the N-terminal leader sequences (LSs) of seed storage proteins. VBPs are defined by a common alpha-hairpin fold mediated by conserved CxxxCx(10-14)CxxxC motifs. Here, peanut and walnut VBPs were characterized as potential mediators of both peanut/walnut allergenicity and cross-reactivity despite their low ( approximately 17%) sequence identity. The structures of one peanut (AH1.1) and 3 walnut (JR2.1, JR2.2, JR2.3) VBPs were solved using solution NMR, revealing similar alpha-hairpin structures stabilized by disulfide bonds with high levels of surface similarity. Peptide microarrays identified several peptide sequences primarily on AH1.1 and JR2.1, which were recognized by peanut-, walnut-, and dual-allergic patient IgE, establishing these peanut and walnut VBPs as potential mediators of allergenicity and cross-reactivity. JR2.2 and JR2.3 displayed extreme resilience against endosomal digestion, potentially hindering epitope generation and likely contributing to their reduced allergic potential. | ||
| + | |||
| + | Structure, Immunogenicity, and IgE Cross-Reactivity among Walnut and Peanut Vicilin-Buried Peptides.,Foo ACY, Nesbit JB, Gipson SAY, Cheng H, Bushel P, DeRose EF, Schein CH, Teuber SS, Hurlburt BK, Maleki SJ, Mueller GA J Agric Food Chem. 2022 Feb 9. doi: 10.1021/acs.jafc.1c07225. PMID:35139305<ref>PMID:35139305</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7lvg" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Juglans regia]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: DeRose EF]] | [[Category: DeRose EF]] | ||
[[Category: Foo ACY]] | [[Category: Foo ACY]] | ||
[[Category: Mueller GA]] | [[Category: Mueller GA]] | ||
Current revision
Jug r 2 Leader Sequence Residues 69-111
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