7w6e
From Proteopedia
(Difference between revisions)
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==Polyketide cyclase OAC-F24I mutant from Cannabis sativa in complex with 6-heptylresorcylic acid== | ==Polyketide cyclase OAC-F24I mutant from Cannabis sativa in complex with 6-heptylresorcylic acid== | ||
| - | <StructureSection load='7w6e' size='340' side='right'caption='[[7w6e]]' scene=''> | + | <StructureSection load='7w6e' size='340' side='right'caption='[[7w6e]], [[Resolution|resolution]] 1.38Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W6E FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7w6e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cannabis_sativa Cannabis sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W6E FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w6e OCA], [https://pdbe.org/7w6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w6e RCSB], [https://www.ebi.ac.uk/pdbsum/7w6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w6e ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8HL:2-heptyl-4,6-bis(oxidanyl)benzoic+acid'>8HL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w6e OCA], [https://pdbe.org/7w6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w6e RCSB], [https://www.ebi.ac.uk/pdbsum/7w6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w6e ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OLIAC_CANSA OLIAC_CANSA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The therapeutic effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) can be enhanced by modifications of the pentyl moiety at C-3. The engineering of Cannabis sativa olivetolic acid cyclase and tetraketide synthase with F24I and L190G substitutions, respectively, in the biosynthesis of Delta(9)-THC serves as a platform for the generation of resorcylic acids up to 6-undecylresorcylic acid. These results provide insights into the development of THC analogs with chemically distinct acyl moieties at C-3. | ||
| + | |||
| + | Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs.,Lee YE, Nakashima Y, Kodama T, Chen X, Morita H Org Lett. 2022 Jan 14;24(1):410-414. doi: 10.1021/acs.orglett.1c04089. Epub 2021 , Dec 23. PMID:34939812<ref>PMID:34939812</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7w6e" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Cannabis sativa]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Lee YE]] | [[Category: Lee YE]] | ||
[[Category: Morita H]] | [[Category: Morita H]] | ||
[[Category: Nakashima Y]] | [[Category: Nakashima Y]] | ||
Current revision
Polyketide cyclase OAC-F24I mutant from Cannabis sativa in complex with 6-heptylresorcylic acid
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