2kqh
From Proteopedia
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==A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics== | ==A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics== | ||
| - | <StructureSection load='2kqh' size='340' side='right'caption='[[2kqh | + | <StructureSection load='2kqh' size='340' side='right'caption='[[2kqh]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kqh]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KQH FirstGlance]. <br> | <table><tr><td colspan='2'>[[2kqh]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2kj2 2kj2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KQH FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [https://pdbe.org/2kqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [https://www.ebi.ac.uk/pdbsum/2kqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqh ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqh OCA], [https://pdbe.org/2kqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqh RCSB], [https://www.ebi.ac.uk/pdbsum/2kqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Guanine-rich DNA sequences with the ability to form quadruplex structures are enriched in the promoter regions of protein-coding genes, particularly those of proto-oncogenes. G-quadruplexes are structurally polymorphic and their folding topologies can depend on the sample conditions. We report here on a structural study using solution state NMR spectroscopy of a second G-quadruplex-forming motif (c-kit2) that has been recently identified in the promoter region of the c-kit oncogene. In the presence of potassium ions, c-kit2 exists as an ensemble of structures that share the same parallel-stranded propeller-type conformations. Subtle differences in structural dynamics have been identified using hydrogen-deuterium exchange experiments by NMR spectroscopy, suggesting the coexistence of at least two structurally similar but dynamically distinct substates, which undergo slow interconversion on the NMR timescale. | ||
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| - | A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.,Hsu ST, Varnai P, Bugaut A, Reszka AP, Neidle S, Balasubramanian S J Am Chem Soc. 2009 Sep 23;131(37):13399-409. PMID:19705869<ref>PMID:19705869</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2kqh" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Balasubramanian | + | [[Category: Balasubramanian S]] |
| - | [[Category: Bugaut | + | [[Category: Bugaut A]] |
| - | [[Category: Hsu | + | [[Category: Hsu S-TD]] |
| - | [[Category: Neidle | + | [[Category: Neidle S]] |
| - | [[Category: Reszka | + | [[Category: Reszka AP]] |
| - | [[Category: Varnai | + | [[Category: Varnai P]] |
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Current revision
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
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