2kze
From Proteopedia
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==Structure of an all-parallel-stranded G-quadruplex formed by hTERT promoter sequence== | ==Structure of an all-parallel-stranded G-quadruplex formed by hTERT promoter sequence== | ||
| - | <StructureSection load='2kze' size='340' side='right'caption='[[2kze | + | <StructureSection load='2kze' size='340' side='right'caption='[[2kze]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kze]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZE FirstGlance]. <br> | <table><tr><td colspan='2'>[[2kze]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZE FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kze OCA], [https://pdbe.org/2kze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kze RCSB], [https://www.ebi.ac.uk/pdbsum/2kze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kze ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kze OCA], [https://pdbe.org/2kze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kze RCSB], [https://www.ebi.ac.uk/pdbsum/2kze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kze ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The catalytic subunit of human telomerase, hTERT, actively elongates the 3' end of the telomere in most cancer cells. The hTERT promoter, which contains many guanine-rich stretches on the same DNA strand, exhibits an exceptional potential for G-quadruplex formation. Here we show that one particular G-rich sequence in this region coexists in two G-quadruplex conformations in potassium solution: a (3 + 1) and a parallel-stranded G-quadruplexes. We present the NMR solution structures of both conformations, each comprising several robust structural elements, among which include the (3 + 1) and all-parallel G-tetrad cores, single-residue double-chain-reversal loops, and a capping A.T base pair. A combination of NMR and CD techniques, complemented with sequence modifications and variations of experimental condition, allowed us to better understand the coexistence of the two G-quadruplex conformations in equilibrium and how different structural elements conspire to favor a particular form. | ||
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| - | Coexistence of two distinct G-quadruplex conformations in the hTERT promoter.,Lim KW, Lacroix L, Yue DJ, Lim JK, Lim JM, Phan AT J Am Chem Soc. 2010 Sep 8;132(35):12331-42. PMID:20704263<ref>PMID:20704263</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2kze" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Lacroix | + | [[Category: Lacroix L]] |
| - | [[Category: Lim | + | [[Category: Lim JKC]] |
| - | [[Category: Lim | + | [[Category: Lim JMW]] |
| - | [[Category: Lim | + | [[Category: Lim KW]] |
| - | [[Category: Phan | + | [[Category: Phan AT]] |
| - | [[Category: Yue | + | [[Category: Yue DJE]] |
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Current revision
Structure of an all-parallel-stranded G-quadruplex formed by hTERT promoter sequence
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Categories: Large Structures | Lacroix L | Lim JKC | Lim JMW | Lim KW | Phan AT | Yue DJE
