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3cqx

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Current revision (12:32, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3cqx' size='340' side='right'caption='[[3cqx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3cqx' size='340' side='right'caption='[[3cqx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3cqx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CQX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3cqx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CQX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hspa8, Hsc70, Hsc73 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Bag2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqx OCA], [https://pdbe.org/3cqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cqx RCSB], [https://www.ebi.ac.uk/pdbsum/3cqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cqx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqx OCA], [https://pdbe.org/3cqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cqx RCSB], [https://www.ebi.ac.uk/pdbsum/3cqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cqx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HSP7C_MOUSE HSP7C_MOUSE]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity). [[https://www.uniprot.org/uniprot/BAG2_MOUSE BAG2_MOUSE]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity).
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[https://www.uniprot.org/uniprot/HSP7C_MOUSE HSP7C_MOUSE] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Misra, S]]
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[[Category: Misra S]]
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[[Category: Nix, J C]]
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[[Category: Nix JC]]
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[[Category: Xu, Z]]
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[[Category: Xu Z]]
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[[Category: Atp-binding]]
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[[Category: Chaperone]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein-protein complex]]
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[[Category: Stress response]]
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Current revision

Chaperone Complex

PDB ID 3cqx

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