SARS-CoV-2 protein M

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==AlphaFold2 Model of Sars-CoV-2 Protein M==
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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='84/842059/Sars-cov-2_protein_m/2'>
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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='84/842059/Sars-cov-2_protein_m/1'>
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{{Theoretical_model}} {{Template:ModelConfidence}}
{{Theoretical_model}} {{Template:ModelConfidence}}
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To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein (UniProt ID: QHD43419) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 4<ref name="MIT_ColabFold"> MIT ColabFold https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb </ref>.
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To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein M (length=222 amino acids, [https://www.uniprot.org/uniprot/P0DTC5 UniProt ID: P0DTC5]) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 4<ref name="MIT_ColabFold">[https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb MIT ColabFold]</ref>.
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== Function ==
== Function ==
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== Function ==
== Function ==
'''Protein M'''
'''Protein M'''
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Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>]
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Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.<ref name="MIT_ColabFold"/><ref name="Zhang_Lab">[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref>
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<ref>pmid 32200634</ref>.
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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[[Image:SARSCoV2_protein_M_250.gif|250px|left|thumb|'''Morph''' of the top 5 ranked [[AlphaFold]]2 models of '''SARS-CoV-2 Protein M''', ''rainbow'' color coded N-C<ref name="MIT_ColabFold"/>.]]
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[[Image:SARSCoV2_protein_M_250.gif|250px|left|thumb|'''Morph''' of the top 5 ranked [[AlphaFold]]2 models of '''SARS-CoV-2 Protein M''', ''rainbow'' color coded N-C (blue to red)<ref name="MIT_ColabFold"/>.]]
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== See also ==
== See also ==
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[[Coronavirus_Disease 2019 (COVID-19)]]
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[[Coronavirus_Disease 2019 (COVID-19)]]<br>
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[[SARS-CoV-2_virus_proteins]]<br>
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[[COVID-19 AlphaFold2 Models]]
__NOTOC__
__NOTOC__
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Current revision

Caption for this structure

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References

  1. ↑ 1.0 1.1 1.2 MIT ColabFold
  2. ↑ Modeling of the SARS-COV-2 Genome
  3. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129

Proteopedia Page Contributors and Editors (what is this?)

Joel L. Sussman, Jaime Prilusky

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