SARS-CoV-2 protein NSP6

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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='84/842052/Backbone_180_color_100-b/1'>
<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='84/842052/Backbone_180_color_100-b/1'>
{{Theoretical_model}} {{Template:ModelConfidence}}
{{Theoretical_model}} {{Template:ModelConfidence}}
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To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein NSP6 color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 3<ref name="MIT_ColabFold"> MIT ColabFold https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb </ref>.
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To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein NSP6 (length = 290 amino acids, NCBI ID [https://www.ncbi.nlm.nih.gov/protein/YP_009725302.1 YP_009725302]) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 3<ref name="MIT_ColabFold">[https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb MIT ColabFold]</ref>.
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== Function ==
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'''Open Reading Frame 10 (ORF10)'''
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== Function ==
== Function ==
'''Non-structural protein 6 (nsp6)'''
'''Non-structural protein 6 (nsp6)'''
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Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes.<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>
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Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes<ref name="MIT_ColabFold"/><ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>.
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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[[Image:SARS-CoV-2_Protein_NSP6.gif|250px|left|thumb|'''Morph''' of the top 5 ranked [[AlphaFold]]2 models of '''SARS-CoV-2 Protein NSP6''', ''rainbow'' color coded N-C<ref name="MIT_ColabFold"/>.]]
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[[Image:NSP6_AlphaFold2_Movie.gif|250px|left|thumb|'''Morph''' of the top 5 ranked [[AlphaFold]]2 models of '''SARS-CoV-2 Protein NSP6''', ''rainbow'' color coded N-C (blue to red)<ref name="MIT_ColabFold"/>.]]
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== See also ==
== See also ==
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[[Coronavirus_Disease 2019 (COVID-19)]]
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[[Coronavirus_Disease 2019 (COVID-19)]]<br>
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[[SARS-CoV-2_virus_proteins]]<br>
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[[COVID-19 AlphaFold2 Models]]
__NOTOC__
__NOTOC__
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Current revision

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References

  1. ↑ 1.0 1.1 1.2 MIT ColabFold
  2. ↑ Modeling of the SARS-COV-2 Genome
  3. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129

Proteopedia Page Contributors and Editors (what is this?)

Joel L. Sussman, Jaime Prilusky

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