SARS-CoV-2 protein ORF10

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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='84/842075/Orf10/2'>
<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='84/842075/Orf10/2'>
{{Theoretical_model}} {{Template:ModelConfidence}}
{{Theoretical_model}} {{Template:ModelConfidence}}
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To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein ORF10 color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 3<ref name="MIT_ColabFold">[https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb MIT ColabFold]</ref>.
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To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein ORF10 (length=38 amino acids, UniProt ID A0A663DJA2 [https://proteopedia.org/wiki/index.php/SARS-CoV-2_protein_ORF10 UniProt ID A0A663DJA2])color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 3<ref name="MIT_ColabFold">[https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb MIT ColabFold]</ref>.
== Function ==
== Function ==
'''Open Reading Frame 10 (ORF10)'''
'''Open Reading Frame 10 (ORF10)'''
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Dubious/uncertain protein. It is currently unclear whether this region translates into a functional protein. The respective region in related beta-coronaviruses, such as SARS-CoV, does not correspond to translated peptide.<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>
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Dubious/uncertain protein. It is currently unclear whether this region translates into a functional protein. The respective region in related beta-coronaviruses, such as SARS-CoV, does not correspond to translated peptide<ref name="MIT_ColabFold"/><ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>.
== Disease ==
== Disease ==
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[[Image:SARS-CoV-2_Protein_ORF10.gif|250px|left|thumb|'''Morph''' of the top 5 ranked [[AlphaFold]]2 models of '''SARS-CoV-2 Protein ORF10''', ''rainbow'' color coded N-C (blue to red)<ref name="MIT_ColabFold"/>.]]
[[Image:SARS-CoV-2_Protein_ORF10.gif|250px|left|thumb|'''Morph''' of the top 5 ranked [[AlphaFold]]2 models of '''SARS-CoV-2 Protein ORF10''', ''rainbow'' color coded N-C (blue to red)<ref name="MIT_ColabFold"/>.]]
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== See also ==
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[[Coronavirus_Disease 2019 (COVID-19)]]<br>
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[[SARS-CoV-2_virus_proteins]]<br>
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[[COVID-19 AlphaFold2 Models]]
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== See also ==
 
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[[Coronavirus_Disease 2019 (COVID-19)]]
 
__NOTOC__
__NOTOC__
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Current revision

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ 1.0 1.1 1.2 MIT ColabFold
  2. ↑ Modeling of the SARS-COV-2 Genome
  3. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129

Proteopedia Page Contributors and Editors (what is this?)

Joel L. Sussman, Jaime Prilusky

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