7trq

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m (Protected "7trq" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 7trq is ON HOLD
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==Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154==
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<StructureSection load='7trq' size='340' side='right'caption='[[7trq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7trq]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TRQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IUI:5-azanyl-3,4-dimethyl-~{N}-[[4-(trifluoromethylsulfonyl)phenyl]methyl]thieno[2,3-c]pyridazine-6-carboxamide'>IUI</scene>, <scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7trq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7trq OCA], [https://pdbe.org/7trq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7trq RCSB], [https://www.ebi.ac.uk/pdbsum/7trq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7trq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACM4_HUMAN ACM4_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
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Authors:
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==See Also==
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*[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]]
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Description:
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*[[Transducin 3D structures|Transducin 3D structures]]
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[[Category: Unreleased Structures]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Belousoff MJ]]
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[[Category: Danev R]]
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[[Category: Glukhova A]]
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[[Category: Mobbs JI]]
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[[Category: Sexton PM]]
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[[Category: Thal DM]]
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[[Category: Vuckovic Z]]

Current revision

Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154

PDB ID 7trq

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