7t7r
From Proteopedia
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==Structure of Munc13-1 C1-C2B-MUN-C2C trimer between lipid bilayers== | ==Structure of Munc13-1 C1-C2B-MUN-C2C trimer between lipid bilayers== | ||
| - | <StructureSection load='7t7r' size='340' side='right'caption='[[7t7r]]' scene=''> | + | <StructureSection load='7t7r' size='340' side='right'caption='[[7t7r]], [[Resolution|resolution]] 10.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7R FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7t7r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7R FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7r OCA], [https://pdbe.org/7t7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7r RCSB], [https://www.ebi.ac.uk/pdbsum/7t7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7r ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7r OCA], [https://pdbe.org/7t7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7r RCSB], [https://www.ebi.ac.uk/pdbsum/7t7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/UN13A_MOUSE UN13A_MOUSE] Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (PubMed:23229896). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (By similarity).[UniProtKB:Q62768][UniProtKB:Q9UPW8]<ref>PMID:10440375</ref> <ref>PMID:12070347</ref> <ref>PMID:15988013</ref> <ref>PMID:16644700</ref> <ref>PMID:16697276</ref> <ref>PMID:17267576</ref> <ref>PMID:17639022</ref> <ref>PMID:23229896</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
[[Category: Grushin K]] | [[Category: Grushin K]] | ||
[[Category: Sindelar CV]] | [[Category: Sindelar CV]] | ||
Current revision
Structure of Munc13-1 C1-C2B-MUN-C2C trimer between lipid bilayers
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