2l4v

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==Three Dimensional Structure of Pineapple Cystatin==
==Three Dimensional Structure of Pineapple Cystatin==
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<StructureSection load='2l4v' size='340' side='right'caption='[[2l4v]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l4v' size='340' side='right'caption='[[2l4v]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anaco Anaco]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ananas_comosus Ananas comosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4V FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4v OCA], [https://pdbe.org/2l4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4v RCSB], [https://www.ebi.ac.uk/pdbsum/2l4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4v ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4v OCA], [https://pdbe.org/2l4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4v RCSB], [https://www.ebi.ac.uk/pdbsum/2l4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4v ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/C9W181_ANACO C9W181_ANACO]
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A cDNA encoding a cysteine protease inhibitor, cystatin was cloned from pineapple (Ananas comosus L.) stem. This clone was constructed into an expression vector and expressed in E. coli and purified to homogeneous. The recombinant pineapple cystatins (AcCYS) showed effectively inhibitory activity toward cysteine proteases including papain, bromelain, and cathepsin B. In order to unravel its inhibitory action from structural point of view, multidimensional heteronuclear NMR techniques were used to characterize the structure of AcCYS. The full (1)H, (15)N, and (13)C resonance assignments of AcCYS were determined. The secondary structure of AcCYS was identified by using the assigned chemical shift of (1)Halpha, (13)Calpha, (13)Cbeta, and (13)CO through the consensus chemical shift index (CSI). The results of CSI analysis suggest 5 beta-strands (residues 45-47, 84-91, 94-104, 106-117, and 123-130) and one alpha-helix (residues 55-73).
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Resonance assignments and secondary structure of a phytocystatin from Ananas comosus.,Irene D, Chen BJ, Lo SH, Liu TH, Tzen JT, Chyan CL Biomol NMR Assign. 2012 Apr;6(1):99-101. doi: 10.1007/s12104-011-9334-1. Epub, 2011 Aug 4. PMID:21814766<ref>PMID:21814766</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2l4v" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Anaco]]
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[[Category: Ananas comosus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, B B.J]]
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[[Category: Chen BBJ]]
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[[Category: Chyan, C C.L]]
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[[Category: Chyan CCL]]
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[[Category: Deli, I I]]
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[[Category: Deli II]]
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[[Category: Cystatin]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Protease inhibitor]]
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Current revision

Three Dimensional Structure of Pineapple Cystatin

PDB ID 2l4v

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