2lt5

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==Zymogen-FLG of the onconase==
==Zymogen-FLG of the onconase==
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<StructureSection load='2lt5' size='340' side='right'caption='[[2lt5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2lt5' size='340' side='right'caption='[[2lt5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2lt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Litpi Litpi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LT5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2lt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_pipiens Lithobates pipiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LT5 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lt5 OCA], [https://pdbe.org/2lt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lt5 RCSB], [https://www.ebi.ac.uk/pdbsum/2lt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lt5 ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lt5 OCA], [https://pdbe.org/2lt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lt5 RCSB], [https://www.ebi.ac.uk/pdbsum/2lt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lt5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RNP30_RANPI RNP30_RANPI]] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.
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[https://www.uniprot.org/uniprot/RNP30_LITPI RNP30_LITPI] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Onconase((R)) FL-G zymogen is a 120 residue protein produced by circular permutation of the native Onconase((R)) sequence. In this construction, the wild type N- and C-termini are linked by a 16 residue segment and new N- and C-termini are generated at wild type positions R73 and S72. This novel segment linking the native N- and C-termini is designed to obstruct Onconase's((R)) active site and encloses a cleavage site for the HIV-1 protease. As a first step towards the resolution of its 3D structure and the study of its structure-function relationships, we report here the nearly complete NMR (1)H, (13)C and (15)N resonance chemical shift assignments at pH 5.2 and 35 degrees C (BMRB deposit no 17973). The results presented here clearly show that the structure of the wild type Onconase((R)) is conserved in the FL-G zymogen.
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(1)H, (13)C and (15)N resonance assignments of the Onconase FL-G zymogen.,Serrano S, Callis M, Vilanova M, Benito A, Laurents DV, Ribo M, Bruix M Biomol NMR Assign. 2012 Mar 4. PMID:22392335<ref>PMID:22392335</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2lt5" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Litpi]]
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[[Category: Lithobates pipiens]]
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[[Category: Bruix, M]]
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[[Category: Bruix M]]
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[[Category: Callis, M]]
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[[Category: Callis M]]
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[[Category: Laurents, D V]]
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[[Category: Laurents DV]]
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[[Category: Ribo, M]]
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[[Category: Ribo M]]
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[[Category: Serrano, S]]
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[[Category: Serrano S]]
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[[Category: Vilanova, M]]
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[[Category: Vilanova M]]
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[[Category: Hydrolase]]
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[[Category: Ribonuclease]]
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Current revision

Zymogen-FLG of the onconase

PDB ID 2lt5

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