7wi8

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'''Unreleased structure'''
 
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The entry 7wi8 is ON HOLD until Paper Publication
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==Cryo-EM structure of inactive mGlu3 bound to LY341495==
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<StructureSection load='7wi8' size='340' side='right'caption='[[7wi8]], [[Resolution|resolution]] 4.17&Aring;' scene=''>
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Authors: Fang, W., Yang, F., Xu, C.J., Ling, S.L., Lin, L., Zhou, Y.X., Sun, W.J., Wang, X.M., Liu, P., Rondard, P., Pan, S., Pin, J.P., Tian, C.L., Liu, J.F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7wi8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WI8 FirstGlance]. <br>
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Description: Cryo-EM structure of inactive mGlu3 bound to LY341495
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wi8 OCA], [https://pdbe.org/7wi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wi8 RCSB], [https://www.ebi.ac.uk/pdbsum/7wi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wi8 ProSAT]</span></td></tr>
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[[Category: Lin, L]]
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</table>
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[[Category: Xu, C.J]]
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== Function ==
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[[Category: Rondard, P]]
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[[https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref>
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[[Category: Tian, C.L]]
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== References ==
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[[Category: Pan, S]]
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<references/>
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[[Category: Liu, P]]
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__TOC__
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[[Category: Wang, X.M]]
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</StructureSection>
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[[Category: Pin, J.P]]
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[[Category: Homo sapiens]]
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[[Category: Ling, S.L]]
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[[Category: Large Structures]]
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[[Category: Fang, W]]
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[[Category: Fang W]]
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[[Category: Zhou, Y.X]]
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[[Category: Lin L]]
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[[Category: Liu, J.F]]
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[[Category: Ling SL]]
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[[Category: Yang, F]]
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[[Category: Liu JF]]
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[[Category: Sun, W.J]]
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[[Category: Liu P]]
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[[Category: Pan S]]
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[[Category: Pin JP]]
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[[Category: Rondard P]]
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[[Category: Sun WJ]]
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[[Category: Tian CL]]
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[[Category: Wang XM]]
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[[Category: Xu CJ]]
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[[Category: Yang F]]
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[[Category: Zhou YX]]

Current revision

Cryo-EM structure of inactive mGlu3 bound to LY341495

PDB ID 7wi8

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OCA

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