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7axu

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Current revision (12:18, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7axu' size='340' side='right'caption='[[7axu]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
<StructureSection load='7axu' size='340' side='right'caption='[[7axu]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7axu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AXU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7axu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AXU FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7axs|7axs]], [[7axq|7axq]], [[7axp|7axp]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7axu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7axu OCA], [https://pdbe.org/7axu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7axu RCSB], [https://www.ebi.ac.uk/pdbsum/7axu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7axu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7axu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7axu OCA], [https://pdbe.org/7axu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7axu RCSB], [https://www.ebi.ac.uk/pdbsum/7axu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7axu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7axu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7axu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Essen, L O]]
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[[Category: Essen L-O]]
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[[Category: Werel, L]]
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[[Category: Werel L]]
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[[Category: Cyclic strained visible-light photoswitch]]
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[[Category: Inhibition of hematopoiesis]]
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[[Category: Mll1 complex disruption]]
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[[Category: Transferase]]
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[[Category: Wdr5]]
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Current revision

Structure of WDR5:CS-VIP8 cocrystal after illumination in situ

PDB ID 7axu

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