2m1g
From Proteopedia
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==Parallel human telomeric quadruplex containing 2'F-ANA substitutions== | ==Parallel human telomeric quadruplex containing 2'F-ANA substitutions== | ||
| - | <StructureSection load='2m1g' size='340' side='right'caption='[[2m1g | + | <StructureSection load='2m1g' size='340' side='right'caption='[[2m1g]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2m1g]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M1G FirstGlance]. <br> | <table><tr><td colspan='2'>[[2m1g]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M1G FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GFL:2-AMINO-9-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1,9-DIHYDRO-6H-PURIN-6-ONE'>GFL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1g OCA], [https://pdbe.org/2m1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m1g RCSB], [https://www.ebi.ac.uk/pdbsum/2m1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m1g ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1g OCA], [https://pdbe.org/2m1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m1g RCSB], [https://www.ebi.ac.uk/pdbsum/2m1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m1g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Human telomeric DNA quadruplexes can adopt different conformations in solution. We have found that arabinose, 2'F-arabinose, and ribose substitutions stabilize the propeller parallel G-quadruplex form over competing conformers, allowing NMR structural determination of this particularly significant nucleic acid structure. 2'F-arabinose substitution provides the greatest stabilization as a result of electrostatic (F-CH---O4') and pseudo-hydrogen-bond (F---H8) stabilizing interactions. In contrast, 2'F-rG substitution provokes a dramatic destabilization of the quadruplex structure due to unfavorable electrostatic repulsion between the phosphate and the 2'-F. | ||
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| - | Dramatic effect of furanose c2' substitution on structure and stability: directing the folding of the human telomeric quadruplex with a single fluorine atom.,Martin-Pintado N, Yahyaee-Anzahaee M, Deleavey GF, Portella G, Orozco M, Damha MJ, Gonzalez C J Am Chem Soc. 2013 Apr 10;135(14):5344-7. doi: 10.1021/ja401954t. Epub 2013 Mar , 27. PMID:23521511<ref>PMID:23521511</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2m1g" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Damha | + | [[Category: Damha MJ]] |
| - | [[Category: Deleavey | + | [[Category: Deleavey GF]] |
| - | [[Category: Gonzalez | + | [[Category: Gonzalez C]] |
| - | [[Category: Martin-Pintado | + | [[Category: Martin-Pintado N]] |
| - | [[Category: Orozco | + | [[Category: Orozco M]] |
| - | [[Category: Portella | + | [[Category: Portella G]] |
| - | [[Category: Yahyaee-Anzahaee | + | [[Category: Yahyaee-Anzahaee M]] |
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Current revision
Parallel human telomeric quadruplex containing 2'F-ANA substitutions
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