2mc5

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==A bacteriophage transcription regulator inhibits bacterial transcription initiation by -factor displacement==
==A bacteriophage transcription regulator inhibits bacterial transcription initiation by -factor displacement==
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<StructureSection load='2mc5' size='340' side='right'caption='[[2mc5]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='2mc5' size='340' side='right'caption='[[2mc5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_phage_xp10 Xanthomonas campestris phage xp10]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MC5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_virus_Xp10 Xanthomonas virus Xp10]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MC5 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mc6|2mc6]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc5 OCA], [https://pdbe.org/2mc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mc5 RCSB], [https://www.ebi.ac.uk/pdbsum/2mc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc5 OCA], [https://pdbe.org/2mc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mc5 RCSB], [https://www.ebi.ac.uk/pdbsum/2mc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc5 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8LTJ5_9CAUD Q8LTJ5_9CAUD]
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Bacteriophages (phages) appropriate essential processes of bacterial hosts to benefit their own development. The multisubunit bacterial RNA polymerase (RNAp) enzyme, which catalyses DNA transcription, is targeted by phage-encoded transcription regulators that selectively modulate its activity. Here, we describe the structural and mechanistic basis for the inhibition of bacterial RNAp by the transcription regulator P7 encoded by Xanthomonas oryzae phage Xp10. We reveal that P7 uses a two-step mechanism to simultaneously interact with the catalytic beta and beta' subunits of the bacterial RNAp and inhibits transcription initiation by inducing the displacement of the sigma70-factor on initial engagement of RNAp with promoter DNA. The new mode of interaction with and inhibition mechanism of bacterial RNAp by P7 underscore the remarkable variety of mechanisms evolved by phages to interfere with host transcription.
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A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement.,Liu B, Shadrin A, Sheppard C, Mekler V, Xu Y, Severinov K, Matthews S, Wigneshweraraj S Nucleic Acids Res. 2014 Jan 30. PMID:24482445<ref>PMID:24482445</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2mc5" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Xanthomonas campestris phage xp10]]
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[[Category: Xanthomonas virus Xp10]]
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[[Category: Liu, B]]
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[[Category: Liu B]]
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[[Category: Matthews, S]]
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[[Category: Matthews S]]
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[[Category: Severinov, K]]
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[[Category: Severinov K]]
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[[Category: Shadrin, A]]
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[[Category: Shadrin A]]
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[[Category: Sheppard, C]]
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[[Category: Sheppard C]]
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[[Category: Wigneshweraraj, S]]
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[[Category: Wigneshweraraj S]]
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[[Category: Xu, Y]]
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[[Category: Xu Y]]
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[[Category: P7]]
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[[Category: Protein binding]]
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[[Category: Rnap]]
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[[Category: Sigma factor]]
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Current revision

A bacteriophage transcription regulator inhibits bacterial transcription initiation by -factor displacement

PDB ID 2mc5

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