3efy

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<StructureSection load='3efy' size='340' side='right'caption='[[3efy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3efy' size='340' side='right'caption='[[3efy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3efy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EFY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3efy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EFY FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cif ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3efy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3efy OCA], [https://pdbe.org/3efy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3efy RCSB], [https://www.ebi.ac.uk/pdbsum/3efy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3efy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3efy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3efy OCA], [https://pdbe.org/3efy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3efy RCSB], [https://www.ebi.ac.uk/pdbsum/3efy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3efy ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q7WRZ5_ECOLX Q7WRZ5_ECOLX]
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Bacterial pathogens have evolved a sophisticated arsenal of virulence factors to modulate host cell biology. Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) use a type III protein secretion system (T3SS) to inject microbial proteins into host cells. The T3SS effector cycle inhibiting factor (Cif) produced by EPEC and EHEC is able to block host eukaryotic cell-cycle progression. We present here a crystal structure of Cif, revealing it to be a divergent member of the superfamily of enzymes including cysteine proteases and acetyltransferases that share a common catalytic triad. Mutation of these conserved active site residues abolishes the ability of Cif to block cell-cycle progression. Finally, we demonstrate that irreversible cysteine protease inhibitors do not abolish the Cif cytopathic effect, suggesting that another enzymatic activity may underlie the biological activity of this virulence factor.
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Structure of the cyclomodulin Cif from pathogenic Escherichia coli.,Hsu Y, Jubelin G, Taieb F, Nougayrede JP, Oswald E, Stebbins CE J Mol Biol. 2008 Dec 12;384(2):465-77. Epub 2008 Sep 27. PMID:18845161<ref>PMID:18845161</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3efy" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hsu, Y]]
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[[Category: Hsu Y]]
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[[Category: Stebbins, C E]]
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[[Category: Stebbins CE]]
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[[Category: Bacteria]]
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[[Category: Cell cycle]]
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[[Category: Cif]]
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[[Category: E. coli]]
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[[Category: Plasmid]]
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[[Category: Type iii secretion]]
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[[Category: Virulence factor]]
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Current revision

Structure of the Cyclomodulin Cif from Pathogenic Escherichia coli

PDB ID 3efy

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