Ribosomal protein S6 kinase

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<StructureSection load='' size='350' side='right' caption='Human ribosomal protein S6 kinase α−1 complex with the inhibitor purvalanol (PDB entry [[2z7s]])' scene='43/434545/Cv/2'>
<StructureSection load='' size='350' side='right' caption='Human ribosomal protein S6 kinase α−1 complex with the inhibitor purvalanol (PDB entry [[2z7s]])' scene='43/434545/Cv/2'>
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__TOC__
== Function ==
== Function ==
[[Ribosomal protein S6 kinase]] (RPS6K) regulates RPS6<ref>PMID:22168436</ref>. RPS6K activity controls the ribosome biogenesis transcriptional program.
[[Ribosomal protein S6 kinase]] (RPS6K) regulates RPS6<ref>PMID:22168436</ref>. RPS6K activity controls the ribosome biogenesis transcriptional program.
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*'''Ribosomal protein S6 kinase alpha''' confers resistance towards therapy of acute myeloid leukaemia using venetoclax/azacitidine<ref>PMID:37414921</ref>.
== Relevance ==
== Relevance ==
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hRPS6K α is over expressed in breast cancer and is associated with poor prognosis<ref>PMID:19085255</ref>. Inhibitors of RPS6S are studied as potential therapeutic agents for treatment of variety of diseases including diabetes and cancer<ref>PMID:24072592</ref>.
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hRPS6K α is overexpressed in breast cancer and is associated with poor prognosis<ref>PMID:19085255</ref>. Inhibitors of RPS6S are studied as potential therapeutic agents for treatment of variety of diseases including diabetes and cancer<ref>PMID:24072592</ref>.
== Structural highlights ==
== Structural highlights ==
The <scene name='43/434545/Cv/5'>inhibitor purvalanol binds hRPS6K in the ATP-binding pocket between the N- and C-terminal lobes</scene><ref>PMID:17965187</ref>. <scene name='43/434545/Cv/6'>Active site</scene>. Water molecule are shown as red sphere.
The <scene name='43/434545/Cv/5'>inhibitor purvalanol binds hRPS6K in the ATP-binding pocket between the N- and C-terminal lobes</scene><ref>PMID:17965187</ref>. <scene name='43/434545/Cv/6'>Active site</scene>. Water molecule are shown as red sphere.
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</StructureSection>
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== 3D Structures of Ribosomal protein S6 kinase ==
== 3D Structures of Ribosomal protein S6 kinase ==
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[[Ribosomal protein S6 kinase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Ribosomal protein S6 kinase α
 
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**[[3rny]], [[2wnt]] - hRPS6K α−1 C-terminal kinase domain - human<br />
 
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**[[1vzo]] - hRPS6K α−5 N-terminal kinase domain (mutant) <br />
 
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**[[3kn6]] - hRPS6K α−5 C-terminal kinase domain<br />
 
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**[[2qr7]], [[2qr8]] - mRPS6K α−3 C-terminal kinase domain (mutant) - mouse<br />
 
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**[[3g51]] - mRPS6K α−3 N-terminal kinase domain<br />
 
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*Ribosomal protein S6 kinase α complex
 
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**[[2z7s]], [[2z7r]] - hRPS6K α−1 N-terminal kinase domain+inhibitor<br />
 
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**[[4nif]] - hRPS6K α−1 C-terminal kinase domain + mitogen-activated protein kinase 1<br />
 
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**[[5csf]], [[5csi]], [[5csj]], [[5csn]] - hRPS6K α−1 residues 683-735 + S100-B<br />
 
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**[[3ubd]] - hRPS6K α−3 N-terminal kinase domain + flavonol glycoside<br />
 
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**[[7opo]] - hRPS6K α−3 N-terminal kinase domain + ORF45<br />
 
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**[[5d9k]], [[5d9l]] - hRPS6K α−3 N-terminal kinase domain + inhibitor<br />
 
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**[[4nus]], [[4nw5]], [[4nw6]] - hRPS6K α−3 N-terminal kinase domain + inhibitor<br />
 
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**[[4d9t]], [[4d9u]], [[4jg6]], [[4jg7]], [[4jg8]], [[5o1s]] - hRPS6K α−3 C-terminal kinase domain + inhibitor<br />
 
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**[[3kn5]] - hRPS6K α−5 C-terminal kinase domain+AMPPNP<br />
 
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**[[2z7q]] - hRPS6K α−1 N-terminal kinase domain + AMPPCP<br />
 
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**[[6g76]], [[6g77]] - hRPS6K α-6 N-terminal kinase domain+AMPPNP<br />
 
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**[[6g78]] - hRPS6K α-6 N-terminal kinase domain (mutant) +AMPPNP<br />
 
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**[[4gue]] - mRPS6K α−3 N-terminal kinase domain + flavonol glycoside<br />
 
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**[[4el9]] - mRPS6K α−3 N-terminal kinase domain + inhibitor<br />
 
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**[[4m8t]], [[4mao]] - mRPS6K α−3 C-terminal kinase domain (mutant) + inhibitor<br />
 
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*Ribosomal protein S6 kinase β
 
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**[[3a60]], [[3a61]], [[3a62]], [[4l3j]], [[4l3l]] - hRPS6K β−1 kinase domain<br />
 
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**[[4l42]], [[4l43]], [[4l44]], [[4l45]], [[4l46]], [[3we4]], [[3wf5]], [[3wf6]], [[4rlo]], [[4rlp]] - hRPS6K β−1 kinase domain + pyrimidine derivative<br />
 
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**[[3wf7]] - hRPS6K β−1 kinase domain + purine derivative<br />
 
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**[[3wf8]], [[3wf9]] - hRPS6K β−1 kinase domain + quinoline derivative<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human ribosomal protein S6 kinase α−1 complex with the inhibitor purvalanol (PDB entry 2z7s)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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