5ska
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c12c4c(ccc1[nH]c(n2)SCc3ncc(c(c3)OCC)C)ncs4, micromolar IC50=0.151839== | |
| - | + | <StructureSection load='5ska' size='340' side='right'caption='[[5ska]], [[Resolution|resolution]] 2.21Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ska]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SKA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=KDC:7-[(4-ethoxy-5-methyl-pyridin-2-yl)methylsulfanyl]-8~{H}-imidazo[4,5-g][1,3]benzothiazole'>KDC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ska FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ska OCA], [https://pdbe.org/5ska PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ska RCSB], [https://www.ebi.ac.uk/pdbsum/5ska PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ska ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Benz J]] | ||
| + | [[Category: Flohr A]] | ||
| + | [[Category: Joseph C]] | ||
| + | [[Category: Krasso A]] | ||
| + | [[Category: Rudolph MG]] | ||
Current revision
CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c12c4c(ccc1[nH]c(n2)SCc3ncc(c(c3)OCC)C)ncs4, micromolar IC50=0.151839
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Categories: Homo sapiens | Large Structures | Benz J | Flohr A | Joseph C | Krasso A | Rudolph MG
