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7r4j

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'''Unreleased structure'''
 
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The entry 7r4j is ON HOLD until Paper Publication
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==Crystal structure of human mitochondrial NAD kinase==
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<StructureSection load='7r4j' size='340' side='right'caption='[[7r4j]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7r4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4j OCA], [https://pdbe.org/7r4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4j RCSB], [https://www.ebi.ac.uk/pdbsum/7r4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4j ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NAKD2_HUMAN NAKD2_HUMAN] Progressive encephalopathy with leukodystrophy due to DECR deficiency. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/NAKD2_HUMAN NAKD2_HUMAN] Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.<ref>PMID:23212377</ref>
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Authors:
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==See Also==
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*[[NAD kinase|NAD kinase]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gelin M]]
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[[Category: Labesse G]]
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[[Category: Lionne C]]
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[[Category: Mary C]]

Current revision

Crystal structure of human mitochondrial NAD kinase

PDB ID 7r4j

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OCA

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