7tlw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Murine Meteorin-like C-terminal NTR domain== | |
| - | + | <StructureSection load='7tlw' size='340' side='right'caption='[[7tlw]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7tlw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TLW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tlw OCA], [https://pdbe.org/7tlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tlw RCSB], [https://www.ebi.ac.uk/pdbsum/7tlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tlw ProSAT]</span></td></tr> |
| - | [[Category: Arndt | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/METRL_MOUSE METRL_MOUSE] Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.<ref>PMID:24906147</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Arndt JW]] | ||
| + | [[Category: Quan C]] | ||
Current revision
Murine Meteorin-like C-terminal NTR domain
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