7yxd

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m (Protected "7yxd" [edit=sysop:move=sysop])
Current revision (13:27, 1 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7yxd is ON HOLD until Paper Publication
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==Crystal structure of WT AncGR2-LBD bound to dexamethasone and SHP coregulator fragment==
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<StructureSection load='7yxd' size='340' side='right'caption='[[7yxd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors: Jimenez-Panizo, A., Estebanez-Perpina, E., Fuentes-Prior, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7yxd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YXD FirstGlance]. <br>
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Description: Crystal structure of WT AncGR2-LBD bound to dexamethasone and SHP coregulator fragment
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Fuentes-Prior, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yxd OCA], [https://pdbe.org/7yxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yxd RCSB], [https://www.ebi.ac.uk/pdbsum/7yxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yxd ProSAT]</span></td></tr>
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[[Category: Jimenez-Panizo, A]]
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</table>
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[[Category: Estebanez-Perpina, E]]
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== Disease ==
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[https://www.uniprot.org/uniprot/NR0B2_HUMAN NR0B2_HUMAN] Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:11136233</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/NR0B2_HUMAN NR0B2_HUMAN] Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.<ref>PMID:14752053</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Unidentified]]
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[[Category: Estebanez-Perpina E]]
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[[Category: Fuentes-Prior P]]
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[[Category: Jimenez-Panizo A]]

Current revision

Crystal structure of WT AncGR2-LBD bound to dexamethasone and SHP coregulator fragment

PDB ID 7yxd

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