1gio

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==NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES==
==NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES==
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<StructureSection load='1gio' size='340' side='right'caption='[[1gio]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='1gio' size='340' side='right'caption='[[1gio]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1gio]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GIO FirstGlance]. <br>
<table><tr><td colspan='2'>[[1gio]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GIO FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gio OCA], [https://pdbe.org/1gio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gio RCSB], [https://www.ebi.ac.uk/pdbsum/1gio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gio ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gio OCA], [https://pdbe.org/1gio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gio RCSB], [https://www.ebi.ac.uk/pdbsum/1gio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gio ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ANG1_BOVIN ANG1_BOVIN]] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity.
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[https://www.uniprot.org/uniprot/ANG1_BOVIN ANG1_BOVIN] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/1gio_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/1gio_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Albaret, C]]
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[[Category: Albaret C]]
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[[Category: Bontems, F]]
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[[Category: Bontems F]]
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[[Category: Lallemand, J Y]]
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[[Category: Lallemand JY]]
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[[Category: Lequin, O]]
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[[Category: Lequin O]]
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[[Category: Spik, G]]
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[[Category: Spik G]]
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[[Category: Endoribonuclease]]
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[[Category: Hydrolase angiogenesis]]
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Current revision

NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES

PDB ID 1gio

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