2mza
From Proteopedia
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==Phosphorylation of CB1 Cannabinoid Receptor Fourth Intracellular Loop pepducins: Effects on Structure and Function== | ==Phosphorylation of CB1 Cannabinoid Receptor Fourth Intracellular Loop pepducins: Effects on Structure and Function== | ||
| - | <StructureSection load='2mza' size='340' side='right'caption='[[2mza | + | <StructureSection load='2mza' size='340' side='right'caption='[[2mza]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2mza]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MZA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2mza]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MZA FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mza OCA], [https://pdbe.org/2mza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mza RCSB], [https://www.ebi.ac.uk/pdbsum/2mza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mza ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mza OCA], [https://pdbe.org/2mza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mza RCSB], [https://www.ebi.ac.uk/pdbsum/2mza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mza ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Chandrashekaran | + | [[Category: Chandrashekaran I]] |
| - | [[Category: Cowsik | + | [[Category: Cowsik S]] |
| - | [[Category: Eldeeb | + | [[Category: Eldeeb K]] |
| - | [[Category: Ganjiwale | + | [[Category: Ganjiwale A]] |
| - | [[Category: Howlett | + | [[Category: Howlett A]] |
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Current revision
Phosphorylation of CB1 Cannabinoid Receptor Fourth Intracellular Loop pepducins: Effects on Structure and Function
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