7t27
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of phage FBB1 anti-CBASS nuclease Acb1-3'3'-cGAMP complex in post reaction state== | |
| - | + | <StructureSection load='7t27' size='340' side='right'caption='[[7t27]], [[Resolution|resolution]] 1.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7t27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Erwinia_phage_FBB1 Erwinia phage FBB1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T27 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ECI:[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-2-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphoryl]oxymethyl]-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphinic+acid'>ECI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t27 OCA], [https://pdbe.org/7t27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t27 RCSB], [https://www.ebi.ac.uk/pdbsum/7t27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t27 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACB1_BPFBB ACB1_BPFBB] Counteracts the host CBASS antiviral defense system. Phosphodiesterase that enables metal-independent hydrolysis of the host cyclic di- and trinucleotide CBASS signals such as 3'3'-cGAMP, 3'3'cUA, and 3'3'3'-cAAA (PubMed:35395152). Does not cleave cGG or cA4 (By similarity). Besides evasion of the CBASS system, might also enable evasion of the type III CRISPR systems that use cA3 signals (By similarity).[UniProtKB:P04533]<ref>PMID:35395152</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Erwinia phage FBB1]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hobbs SJ]] | ||
| + | [[Category: Kranzusch PJ]] | ||
| + | [[Category: Lu A]] | ||
| + | [[Category: Morehouse BR]] | ||
| + | [[Category: Schnabel J]] | ||
| + | [[Category: Sorek R]] | ||
| + | [[Category: Wein T]] | ||
Current revision
Structure of phage FBB1 anti-CBASS nuclease Acb1-3'3'-cGAMP complex in post reaction state
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Categories: Erwinia phage FBB1 | Large Structures | Hobbs SJ | Kranzusch PJ | Lu A | Morehouse BR | Schnabel J | Sorek R | Wein T
