7wz6

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'''Unreleased structure'''
 
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The entry 7wz6 is ON HOLD until Paper Publication
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==Crystal structure of MyoD-E47==
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<StructureSection load='7wz6' size='340' side='right'caption='[[7wz6]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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Authors: Zhong, J., Huang, Y., Ma, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7wz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WZ6 FirstGlance]. <br>
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Description: Crystal structure of MyoD-E47
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wz6 OCA], [https://pdbe.org/7wz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wz6 RCSB], [https://www.ebi.ac.uk/pdbsum/7wz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wz6 ProSAT]</span></td></tr>
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[[Category: Zhong, J]]
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</table>
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[[Category: Ma, J]]
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== Function ==
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[[Category: Huang, Y]]
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[https://www.uniprot.org/uniprot/TFE2_MOUSE TFE2_MOUSE] Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (PubMed:15226298, PubMed:18214987). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (PubMed:18214987). Together with TCF15, required for the mesenchymal to epithelial transition (PubMed:11309385, PubMed:15226298). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (PubMed:15226298, PubMed:18214987, PubMed:30426815). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (PubMed:2181401).[UniProtKB:P15923]<ref>PMID:11309385</ref> <ref>PMID:15226298</ref> <ref>PMID:18214987</ref> <ref>PMID:2181401</ref> Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity.[UniProtKB:P15923]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Huang Y]]
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[[Category: Ma J]]
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[[Category: Zhong J]]

Current revision

Crystal structure of MyoD-E47

PDB ID 7wz6

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OCA

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