7yzd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the zebrafish FoxH1 bound to the TGTTTACT site (fkh motif GTAAACA)== | |
| - | + | <StructureSection load='7yzd' size='340' side='right'caption='[[7yzd]], [[Resolution|resolution]] 2.13Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7yzd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YZD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yzd OCA], [https://pdbe.org/7yzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yzd RCSB], [https://www.ebi.ac.uk/pdbsum/7yzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yzd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FOXH1_DANRE FOXH1_DANRE] Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry.<ref>PMID:10996071</ref> <ref>PMID:10996072</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Danio rerio]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Macias MJ]] | ||
| + | [[Category: Pluta R]] | ||
Current revision
Crystal structure of the zebrafish FoxH1 bound to the TGTTTACT site (fkh motif GTAAACA)
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