1pou
From Proteopedia
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==THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN== | ==THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN== | ||
| - | <StructureSection load='1pou' size='340' side='right'caption='[[1pou | + | <StructureSection load='1pou' size='340' side='right'caption='[[1pou]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1pou]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1pou]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1POU FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pou OCA], [https://pdbe.org/1pou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pou RCSB], [https://www.ebi.ac.uk/pdbsum/1pou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pou ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pou OCA], [https://pdbe.org/1pou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pou RCSB], [https://www.ebi.ac.uk/pdbsum/1pou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pou ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PO2F1_HUMAN PO2F1_HUMAN] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.<ref>PMID:1684878</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Assa-Munt | + | [[Category: Assa-Munt N]] |
| - | [[Category: Aurora | + | [[Category: Aurora R]] |
| - | [[Category: Herr | + | [[Category: Herr W]] |
| - | [[Category: Mortishire-Smith | + | [[Category: Mortishire-Smith RJ]] |
| - | [[Category: Wright | + | [[Category: Wright PE]] |
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Current revision
THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN
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