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1ugv

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Current revision (23:53, 27 December 2023) (edit) (undo)
 
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==Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)==
==Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)==
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<StructureSection load='1ugv' size='340' side='right'caption='[[1ugv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1ugv' size='340' side='right'caption='[[1ugv]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ugv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UGV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ugv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UGV FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA hg04539 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ugv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugv OCA], [https://pdbe.org/1ugv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ugv RCSB], [https://www.ebi.ac.uk/pdbsum/1ugv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ugv TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ugv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugv OCA], [https://pdbe.org/1ugv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ugv RCSB], [https://www.ebi.ac.uk/pdbsum/1ugv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ugv TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[https://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
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[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[https://omim.org/entry/607785 607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] GTPase-activating protein for RHOA and CDC42.
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[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN] GTPase-activating protein for RHOA and CDC42.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aoki, M]]
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[[Category: Aoki M]]
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[[Category: Hayashi, F]]
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[[Category: Hayashi F]]
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[[Category: Hirota, H]]
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[[Category: Hirota H]]
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[[Category: Inoue, K]]
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[[Category: Inoue K]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Kikuno, R]]
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[[Category: Kikuno R]]
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[[Category: Matsuda, T]]
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[[Category: Matsuda T]]
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[[Category: Matsuo, Y]]
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[[Category: Matsuo Y]]
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[[Category: Nagase, T]]
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[[Category: Nagase T]]
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[[Category: Nakayama, M]]
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[[Category: Nakayama M]]
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[[Category: Ohara, O]]
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[[Category: Ohara O]]
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[[Category: Osanai, T]]
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[[Category: Osanai T]]
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[[Category: Structural genomic]]
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[[Category: Seki E]]
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[[Category: Seki, E]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M]]
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[[Category: Tanaka A]]
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[[Category: Tanaka, A]]
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[[Category: Terada T]]
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[[Category: Terada, T]]
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[[Category: Yabuki T]]
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[[Category: Yabuki, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Yoshida M]]
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[[Category: Yoshida, M]]
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[[Category: Beta barrel]]
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[[Category: Graf protein]]
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[[Category: Protein binding]]
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[[Category: Rsgi]]
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Current revision

Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)

PDB ID 1ugv

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OCA

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