1wgg

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==Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14)==
==Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14)==
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<StructureSection load='1wgg' size='340' side='right'caption='[[1wgg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1wgg' size='340' side='right'caption='[[1wgg]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wgg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WGG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wgg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WGG FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">REKIN cDNA 2610005K12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitin_thiolesterase Ubiquitin thiolesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.15 3.1.2.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wgg OCA], [https://pdbe.org/1wgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wgg RCSB], [https://www.ebi.ac.uk/pdbsum/1wgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wgg ProSAT], [https://www.topsan.org/Proteins/RSGI/1wgg TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wgg OCA], [https://pdbe.org/1wgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wgg RCSB], [https://www.ebi.ac.uk/pdbsum/1wgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wgg ProSAT], [https://www.topsan.org/Proteins/RSGI/1wgg TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/UBP14_MOUSE UBP14_MOUSE]] Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Maintains the cellular levels of monomeric ubiquitin in cells. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor cxcr4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1.<ref>PMID:16190881</ref> <ref>PMID:19726649</ref>
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[https://www.uniprot.org/uniprot/UBP14_MOUSE UBP14_MOUSE] Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Maintains the cellular levels of monomeric ubiquitin in cells. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor cxcr4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1.<ref>PMID:16190881</ref> <ref>PMID:19726649</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Ubiquitin thiolesterase]]
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[[Category: Inoue M]]
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[[Category: Inoue, M]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T]]
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[[Category: Koshiba S]]
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[[Category: Koshiba, S]]
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[[Category: Tomizawa T]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama S]]
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[[Category: Tomizawa, T]]
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[[Category: Zhao C]]
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[[Category: Yokoyama, S]]
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[[Category: Zhao, C]]
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[[Category: Hydrolase]]
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[[Category: Rsgi]]
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[[Category: Ubiquitin specific protease 14]]
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[[Category: Ubiquitin-like fold]]
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[[Category: Usp14]]
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Current revision

Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14)

PDB ID 1wgg

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