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1z9e

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Current revision (08:10, 15 May 2024) (edit) (undo)
 
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==Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75==
==Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75==
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<StructureSection load='1z9e' size='340' side='right'caption='[[1z9e]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='1z9e' size='340' side='right'caption='[[1z9e]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1z9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z9E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1z9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z9E FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PSIP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z9e OCA], [https://pdbe.org/1z9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z9e RCSB], [https://www.ebi.ac.uk/pdbsum/1z9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z9e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z9e OCA], [https://pdbe.org/1z9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z9e RCSB], [https://www.ebi.ac.uk/pdbsum/1z9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z9e ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN]] Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
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[https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN] Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN]] Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.<ref>PMID:15642333</ref>
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[https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN] Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.<ref>PMID:15642333</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cherepanov, P]]
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[[Category: Cherepanov P]]
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[[Category: Engelman, A]]
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[[Category: Engelman A]]
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[[Category: Maertens, G]]
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[[Category: Maertens G]]
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[[Category: Rahman, S]]
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[[Category: Rahman S]]
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[[Category: Sun, Z Y.J]]
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[[Category: Sun Z-YJ]]
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[[Category: Wagner, G]]
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[[Category: Wagner G]]
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[[Category: Heat repeat-like]]
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[[Category: Ledgf]]
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[[Category: Protein binding-transcription complex]]
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Current revision

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

PDB ID 1z9e

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