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3foe
From Proteopedia
(Difference between revisions)
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<StructureSection load='3foe' size='340' side='right'caption='[[3foe]], [[Resolution|resolution]] 4.00Å' scene=''> | <StructureSection load='3foe' size='340' side='right'caption='[[3foe]], [[Resolution|resolution]] 4.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3foe]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3foe]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FOE FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.001Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NFX:7-[(3R)-3-AMINOPYRROLIDIN-1-YL]-8-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>NFX</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3foe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3foe OCA], [https://pdbe.org/3foe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3foe RCSB], [https://www.ebi.ac.uk/pdbsum/3foe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3foe ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3foe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3foe OCA], [https://pdbe.org/3foe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3foe RCSB], [https://www.ebi.ac.uk/pdbsum/3foe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3foe ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Fisher, L M]] | ||
| - | [[Category: Laponogov, I]] | ||
| - | [[Category: McAuley, K E]] | ||
| - | [[Category: Pan, X S]] | ||
| - | [[Category: Sanderson, M R]] | ||
| - | [[Category: Sawhney, R]] | ||
| - | [[Category: Sohi, M K]] | ||
| - | [[Category: Thompson, A W]] | ||
| - | [[Category: Veselkov, D A]] | ||
| - | [[Category: Atp-binding]] | ||
| - | [[Category: Cell membrane]] | ||
| - | [[Category: Clinafloxacin]] | ||
| - | [[Category: Dna]] | ||
| - | [[Category: Dna-binding]] | ||
| - | [[Category: Isomerase]] | ||
| - | [[Category: Isomerase-dna complex]] | ||
| - | [[Category: Membrane]] | ||
| - | [[Category: Nucleotide-binding]] | ||
| - | [[Category: Protein-dna cleavage complex]] | ||
| - | [[Category: Quinolone]] | ||
[[Category: Streptococcus pneumoniae]] | [[Category: Streptococcus pneumoniae]] | ||
| - | [[Category: | + | [[Category: Fisher LM]] |
| + | [[Category: Laponogov I]] | ||
| + | [[Category: McAuley KE]] | ||
| + | [[Category: Pan X-S]] | ||
| + | [[Category: Sanderson MR]] | ||
| + | [[Category: Sawhney R]] | ||
| + | [[Category: Sohi MK]] | ||
| + | [[Category: Thompson AW]] | ||
| + | [[Category: Veselkov DA]] | ||
Current revision
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
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