7tre

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'''Unreleased structure'''
 
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The entry 7tre is ON HOLD until Paper Publication
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==Human telomerase catalytic core with shelterin protein TPP1==
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<StructureSection load='7tre' size='340' side='right'caption='[[7tre]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7tre]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TRE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tre OCA], [https://pdbe.org/7tre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tre RCSB], [https://www.ebi.ac.uk/pdbsum/7tre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tre ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACD_HUMAN ACD_HUMAN] Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.<ref>PMID:15181449</ref> <ref>PMID:16166375</ref> <ref>PMID:16880378</ref> <ref>PMID:20231318</ref> <ref>PMID:17237768</ref>
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Authors:
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==See Also==
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*[[Telomerase 3D structures|Telomerase 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Feigon J]]
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[[Category: He Y]]
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[[Category: Liu B]]
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[[Category: Song H]]
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[[Category: Wang Y]]
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[[Category: Zhou ZH]]

Current revision

Human telomerase catalytic core with shelterin protein TPP1

PDB ID 7tre

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OCA

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