This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7x41
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7x41 is ON HOLD until Paper Publication Authors: Chang, Y.T., Chuang, W.J. Description: Crystal structure of chlorotoxin, a glioma specific scorpio...) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of chlorotoxin, a glioma specific scorpion toxin== | |
| - | + | <StructureSection load='7x41' size='340' side='right'caption='[[7x41]], [[Resolution|resolution]] 1.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7x41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X41 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x41 OCA], [https://pdbe.org/7x41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x41 RCSB], [https://www.ebi.ac.uk/pdbsum/7x41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x41 ProSAT]</span></td></tr> |
| - | [[Category: Chang | + | </table> |
| - | [[Category: Chuang | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CTXL_LEIQU CTXL_LEIQU] This toxin binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae (PubMed:16520829). It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface (PubMed:12454020).<ref>PMID:12454020</ref> <ref>PMID:16520829</ref> <ref>PMID:8383429</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Leiurus quinquestriatus quinquestriatus]] | ||
| + | [[Category: Chang YT]] | ||
| + | [[Category: Chuang WJ]] | ||
Current revision
Crystal structure of chlorotoxin, a glioma specific scorpion toxin
| |||||||||||
