3g9v

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<StructureSection load='3g9v' size='340' side='right'caption='[[3g9v]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
<StructureSection load='3g9v' size='340' side='right'caption='[[3g9v]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3g9v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G9V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3g9v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G9V FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL22RA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL22 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.756&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g9v OCA], [https://pdbe.org/3g9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g9v RCSB], [https://www.ebi.ac.uk/pdbsum/3g9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g9v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g9v OCA], [https://pdbe.org/3g9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g9v RCSB], [https://www.ebi.ac.uk/pdbsum/3g9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g9v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/I22R2_HUMAN I22R2_HUMAN]] Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.<ref>PMID:11390454</ref> <ref>PMID:11390453</ref> <ref>PMID:11481447</ref> Isoform 1 may play a role in establishing and maintaining successful pregnancy.<ref>PMID:11390454</ref> <ref>PMID:11390453</ref> <ref>PMID:11481447</ref> [[https://www.uniprot.org/uniprot/IL22_HUMAN IL22_HUMAN]] Cytokine that contributes to the inflammatory response in vivo.
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[https://www.uniprot.org/uniprot/I22R2_HUMAN I22R2_HUMAN] Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.<ref>PMID:11390454</ref> <ref>PMID:11390453</ref> <ref>PMID:11481447</ref> Isoform 1 may play a role in establishing and maintaining successful pregnancy.<ref>PMID:11390454</ref> <ref>PMID:11390453</ref> <ref>PMID:11481447</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/3g9v_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/3g9v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bleicher, L]]
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[[Category: Bleicher L]]
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[[Category: Colau, D]]
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[[Category: Colau D]]
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[[Category: Moura, P R.de]]
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[[Category: Polikarpov I]]
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[[Category: Polikarpov, I]]
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[[Category: Renauld J-C]]
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[[Category: Renauld, J C]]
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[[Category: Watanabe L]]
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[[Category: Watanabe, L]]
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[[Category: De Moura PR]]
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[[Category: Cytokine]]
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[[Category: Cytokine receptor]]
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[[Category: Cytokine-cytokine receptor complex]]
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[[Category: Glycoprotein]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Secreted]]
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Current revision

Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22

PDB ID 3g9v

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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