3ggq

<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hev-1 Hev-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33774 HEV-1])</td></tr>

[[https://www.uniprot.org/uniprot/CAPSD_HEVPA CAPSD_HEVPA]] Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).

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== Publication Abstract from PubMed ==

Hepatitis E virus (HEV), a non-enveloped, positive-stranded RNA virus, is transmitted in a faecal-oral manner, and causes acute liver diseases in humans. The HEV capsid is made up of capsomeres consisting of homodimers of a single structural capsid protein forming the virus shell. These dimers are believed to protrude from the viral surface and to interact with host cells to initiate infection. To date, no structural information is available for any of the HEV proteins. Here, we report for the first time the crystal structure of the HEV capsid protein domain E2s, a protruding domain, together with functional studies to illustrate that this domain forms a tight homodimer and that this dimerization is essential for HEV-host interactions. In addition, we also show that the neutralizing antibody recognition site of HEV is located on the E2s domain. Our study will aid in the development of vaccines and, subsequently, specific inhibitors for HEV.

Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction.,Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H, Shih JW, Hew CL, Sivaraman J, Xia N PLoS Pathog. 2009 Aug;5(8):e1000537. Epub 2009 Aug 7. PMID:19662165<ref>PMID:19662165</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 3ggq" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Hev-1]]

[[Category: Du, H L]]

[[Category: Gu, Y]]

[[Category: Hew, C L]]

[[Category: Li, S W]]

[[Category: Seetharaman, J]]

[[Category: Shih, J W.K]]

[[Category: Sivaraman, J]]

[[Category: Tang, X H]]

[[Category: Xia, N S]]

[[Category: Yang, C Y]]

[[Category: Zhang, J]]

[[Category: Viral protein]]