7x4t

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'''Unreleased structure'''
 
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The entry 7x4t is ON HOLD until Paper Publication
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==LpCdnE UMPNPP Mg complex==
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<StructureSection load='7x4t' size='340' side='right'caption='[[7x4t]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7x4t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X4T FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2KH:5-O-[(S)-HYDROXY{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]URIDINE'>2KH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x4t OCA], [https://pdbe.org/7x4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x4t RCSB], [https://www.ebi.ac.uk/pdbsum/7x4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x4t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDNE2_LEGPN CDNE2_LEGPN] CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection (Probable). A type I-B(UU) CBASS system (PubMed:32839535).<ref>PMID:32839535</ref> <ref>PMID:32839535</ref> Cyclic dinucleotide synthase that catalyzes the synthesis of 3',3'-cyclic UMP-UMP (c-di-UMP) as the major product, and of 3',3'-cyclic CMP-UMP as a minor product, that are second messengers for cell signal transduction.<ref>PMID:30787435</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Legionella pneumophila]]
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[[Category: Chen Y]]
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[[Category: Hou MH]]
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[[Category: Ko TP]]
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[[Category: Wang YC]]
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[[Category: Yang CS]]

Current revision

LpCdnE UMPNPP Mg complex

PDB ID 7x4t

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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